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HSIL Pap smear

A normal Pap smear shows healthy squamous cells (flat cells that look like fish scales) from the surface of the cervix. There are no signs of infection and no abnormal cells. Even if your Pap results are healthy, you should be tested regularly. The tests screen for infectious agents that may be harmful if allowed to persist HSIL changes seen on a Pap test can be CIN 2, CIN2/3, or CIN 3. CIN 1 changes are mild, or low grade. They usually go away on their own and do not require treatment. CIN 2 changes are moderate and are typically treated by removing the abnormal cells

High grade squamous intraepithelial lesion or HSIL is a finding on the cervical tissues following a Pap smear. HSIL is a type of cervical dysplasia found in microscopic analysis of the cervical cells. Cervical dysplasia refers to the occurrence of pre-malignant or precancerous cells in the cervix and opening of the uterus A diagnosis of LSIL or HSIL doesn't necessarily equal cancer. Plus, the presence of squamous intraepithelial lesions on your Pap smear doesn't increase your chances of precancer or cancer. Instead, the main culprit behind cervical cancer is infection with HPV

Abnormal Pap Test Results: Kimmel Cancer Cente

A high grade squamous intraepithelial lesion on Pap smear does not indicate cancer. It usually indicates what is called moderate or severe dysplasia. However, since the Pap smear is a screening test, the actual changes on the cervix can be worse and actually be an invasive cervical cancer Overall, there is a moderate risk that a Pap smear read as LSIL will progress to high-grade squamous intraepithelial lesions (HSIL) on follow-up or that HSIL will be present on biopsy. In contrast, roughly half of Pap smears read as LSIL will regress (return to normal) Major cytological abnormalities (HSIL and ASC-H) on the referral pap smear were significantly more frequent than lesser abnormalities (ASC-US and LSIL) in postmenopausal women (64.9% vs 36.7%, P = 0.02) and in women with a previous diagnosis of HPV-related cervical preinvasive or invasive lesions (70.5% vs 39.5%, P = 0.01)

Understanding HPV and Pap Test Results - National Cancer

High Grade Squamous Intraepithelial Lesion (HGSIL

Pathologists look at slides containing cervical cells from pap smears all day long, and sometimes they see a cell or cells that looks a lot like an HSIL cell, but really it was a normal cell that just happened to be a little oddly shaped High-grade squamous intraepithelial lesions are typically discovered during a routine pap smear. A high-grade squamous intraepithelial lesion, also called HSIL or HGSIL, is an abnormal growth of cells on the cervix. These cells are found in a Pap smear. The presence of HSIL is often linked to cervical cancer. The diagnosis usually indicates the. Hello, I recently had an abnormal pap smear result of HSIL. I then underwent colposcopy with biopsies and an ECC. These results all came back normal (not even mild dysplasia). My gynecologist suggested that because there was such a large discrepancy between the Pap and the biopsy results that a LEEP procedure be done HSIL indicates squamous cells that appear very abnormal and signify the possibility of a precancer or cancer of the cervix. AGC indicates glandular cells on a Pap test that appear abnormal. Glandular cells on a Pap test are usually cells from the cervical canal but may also come from the uterus

Uterine Cervix Cytopathology | Cellnetpathology

- if pap negative at 12 months then Q3yr pap smear - if pap ASUCS,ASC_H,LSIL,HSIL,AGUS,AIS or CIS at 12 months then proceed to colposcopy. *Remember in this category (25-29 yr old)if repeat at 12 month is abnormal even if ASUCUS - Proceed to colposcop ASCCP recently released its Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors 1 .The new consensus guidelines are an update of the 2012 ASCCP management guidelines and were developed with input from 19 stakeholder organizations, including ACOG, to provide recommendations for the care of patients with abnormal cervical cancer screening. On review of final diagnoses for Pap smears that were initially labeled AGUS, HPV DNA was detected in 92 percent of women with high-grade squamous intraepithelial lesions, 56 percent with low. High grade squamous intraepithelial lesion (HSIL) is a pre-cancerous disease that develops in the cervix. HSIL is caused by a virus called human papillomavirus (HPV). If left untreated, patients with HSIL are at high risk for developing a cancer of the cervix called squamous carcinoma The diagnosis of ASC-H on Pap smear is associated with an appreciable risk of clinically significant disease. Patients with an ASC-H Pap smear result should undergo timely colposcopic and histologic assessment to rule out HSIL, AIS, and cervical cancer

HSIL or cancer (HSIL+) Pap test, or of a negative biopsy and an HSIL or cancer Pap test re-interpreted as NILM (negative for intraepithial lesion or malignancy). • Laboratories should attempt to obtain correlation biopsy information for all patients with an HSIL or cancer Pap test HGSIL (cytology finding) (high grade squamous intraepithelial lesion on cytologic smear) (Pap smear finding) cervix R87.613 Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes A LSIL, or abnormal Pap result, doesn't mean that you have cancer. The tissue that covers your cervix is made up of squamous cells. Pap tests are used to screen for cervical cancer, precancer, and..

Hasil Pap smear yang abnormal tidak selalu menunjukkan adanya kanker. Sel kadang tampak abnormal namun tidak bersifat kanker. Wanita itu harus kembali ke dokter untuk perawatan lanjutan. Infeksi pada serviks dapat menyebabkan hasil tes abnormal. Ragi, trikomonas, klamidia, atau infeksi gonore dapat menyebabkan sel-sel serviks tampak meradang If the Pap smear is HSIL the recommendation is for you to have a colposcopy. A colposcope allows your healthcare provider to view the cells on your cervix more closely (it's like looking under a microscope) and possibly take samples of abnormal cells for further evaluation by a laboratory. This is called a biopsy pap smear tells us there is an abnormality (atypical) in the cells that make mucus (glandular cells) 11% of patients have: high-grade squamous intraepithelial lesions (HSIL). This is a precancerous spot that has a moderate to high chance of becoming cervical cancer. 3% of patients have: adenocarcinoma in situ. This is a precancerous spot. The current nomenclature now used to report Pap findings in the United States began with a meeting of a small group of experts in December of 1988 in Bethesda, Maryland. a Pap smear has to have Of all women with HSIL results, 2% or less have invasive cervical cancer at the time of diagnosis

When atypical glandular cells were noted on Pap smears, the likelihood for histologic diagnosis of adenocarcinoma following Pap smear was higher than that of high-risk HPV test results (18.8 and 1.53, respectively). Conclusions: Pap smears were more useful than HPV tests in the diagnosis of HSIL, SCC, and glandular lesions Pap smear guidelines can get confusing quickly, and are much easier to navigate when keeping a few major components in mind. These following factors are foundational in dictating our management when thinking about pap smears. Pap smear results: In this case, the patient has a result of HSIL on a routine pap smear HSIL Pap Smear is a typically identified matter in light of the fact that it is of concern when pondering How To Do A Pap Smear, How To Get A Pap Smear, and How To Get Pap Smear Results. Someone could strengthen the immune system and generally establish resistance to an HPV virus in only just a couple of months , sooner than it might create any. This is the most typical abnormal Pap smear result. Squamous intraepithelial lesion (SIL). Abnormal changes that may signal precancer. These can be either low-grade (LSIL) or high-grade (HSIL), depending on the severity of dysplasia. LSIL usually clears up on its own, but HSIL is likely to progress to cancer if left untreated Only 0.5 percent of cytologic samples demonstrate high-grade squamous intraepithelial lesion (HSIL).25 Of women with HSIL, 70 to 75 percent will have CIN 2,3 and 1 to 4 percent will have invasion.

Pap smear, repeat colposcopy is likely the most appropriate option. Repeat Pap smears in Colposcopy Clinics: If the abnormal Pap smear is >12 months prior to current assessment, and colposcopic evaluation is negative for HSIL, consider repeating cytology prior to proceeding with diagnostic LEEP •with ASC-H or HSIL cytology, but colposcopy with no lesion or biopsy-confirmed CIN 1 •with ASC-US, ASC-H cytology and LSIL, HSIL, AGC confirmed by biopsy • If either Pap smear or HPV testing are positive, co-testing is integrated into follow-up care; colposcopy, HPV DNA typing, or both may be indicated. Thank you! Pap smear showed HGSIL with features of suspicious invasion. Chances of cervical cancer? Posted on Tue, 12 Mar 2013 . Question: My wife had a pap smear done recently. It came back HGSIL with features of suspicious invasion. The features of suspicious invasion. Is that a term that means cancer is detected This tissue is sent for pathology testing to assign a histologic classification that is more definitive than a Pap smear result (which is a cytologic finding). HSIL generally corresponds to the histological classification of CIN 2 or 3. HSIL treatment involves the removal or destruction of the affected cells, usually by LEEP I recently had an abnormal Pap smear of HSIL and underwent subsequent colposcopy with ECC and biopsies. These came back as normal. My gyno wanted to perform a LEEP procedure which was done 2 days ago. read mor

Low-Grade Squamous Intraepithelial Lesion: When Pap Smear

  1. For an HSIL or ASC-H abnormal Pap smear result: No matter your age, a doctor will likely recommend more procedures like a colposcopy after HSIL or ASC-H abnormal Pap smear results, according to ACOG
  2. High Grade HSIL Pap Letter Patient Diagnosis: High Grade Squamous Intraepithelial Lesion (HSIL) The Pap test is intended to detect cancer and changes that may lead to cancer. The Pap test recently performed by your Doctor has shown some abnormal cell changes of High Grade Squamous Intraepithelial Lesion (HSIL)
  3. Abnormal Pap Smear and Cervical Cancer. The Pap test checks for changes in the cervix that may become cancer. If a Pap test shows these changes, the result is called abnormal. In women who have regular Pap tests, abnormal changes are almost always caught early. An abnormal Pap test result may mean that further testing and follow-up are needed
  4. If abnormal Pap smears persist for 1 year, or if an HSIL Pap smear is obtained at any time, colposcopy should be performed. HSIL. There is no controversy about management of patients with high.
  5. hsil pap smear treatment during pregnancy. A 36-year-old female asked: i am 20 weeks pregnant, pap smear came back as hsil. could pregnancy be the cause and should i consent to biopsies? Dr. Parul Krishnamurthy answered. 34 years experience Obstetrics and Gynecology
  6. Relative risk for ASC-H Pap diagnosis is certainly less than 20%, but HSIL must first be excluded by colposcopy and biopsy after ASC-H findings. If no colposcopic lesion is visible in follow up of ASC-H, vigorous ECC should be undertaken

A diagnosis of LSIL or HSIL doesn't necessarily equal cancer. Plus, the presence of squamous intraepithelial lesions on your Pap smear doesn't increase your chances of precancer or cancer. Instead, the main culprit behind cervical cancer is infection with HPV. Several types of HPV have been linked to cancer of the vulva, vagina, penis, anus. be used as a 'test of cure' after the treatment of an HSIL. The woman should return to her gynaecologist for a repeat colposcopy and Pap test 4-6 months after treatment of an HSIL. If these are satisfactory, she can see her usual practitioner 12 months post-treatment for both a Pap and HPV test. These two tests should be done annually unti

Visit Cytoweb for more! https://blog.nus.edu.sg/cytoweb She has had normal Pap smears as recommended every 3 years since she turned 30 years old. The physician conducts a pelvic examination that is without abnormality and obtains a cervical Pap smear. The results of the patient's Pap smear from the visit return as high grade squamous intraepithelial lesion (HGSIL) If there is an abnormality, then colposcopy should be performed. If the initial Pap was high grade (ASC-H or HSIL): recommend repeat cotesting at 12 and 24 months. If normal at both intervals, then can have repeat testing in 3 years before resuming normal age-appropriate intervals

The best way to do that is by sampling the cells of the anus with a Pap smear. An anal Pap smear is performed to screen for anal HSIL in the following manner. Patients are asked not to douche or have an enema or insert anything into their anus for 24 hours prior to an anal cytology exam. Lubricants should not be used prior to obtaining a. The Pap test (Pap smear, cervical smear) is a screening test that looks for abnormal cells in the vaginal portion of the uterine cervix. (HSIL). The Pap test is designed to look for both squamous cell carcinoma and HSIL. The Pap test can also identify infection causing microorganisms including: Candida species. Trichomonas vaginalis. If the patient has previously been evaluated for an abnormal Pap and found to have either mild dysplasia or HPV changes, the occurrence of an occasional ASC-US smear is not surprising and is often considered normal for that person. In higher risk circumstances, further colposcopy is sometimes undertaken to re-evaluate the cervix

HGSIL of the Cervix on Pap Smear: What it Mean

  1. This same age-group of women with Pap smear results showing atypical squamous cells-cannot exclude high grade (ASC-H), atypical glandular cells, or HGSIL results on repeat cytology; colposcopy is the recommendation. For follow-up Pap smears showing ASCUS, LGSIL or negative, the recommendation is to repeat in another 12 months
  2. If a pregnant woman is diagnosed with HSIL, she will usually have a repeat colposcopy or treatment 8 to 12 weeks after she has her baby. Some women with HSIL will need to have more tests such as a colposcopy, a Pap test or another biopsy during pregnancy. A cone biopsy is not usually done during pregnancy because there is a small risk of bleeding
  3. A large (N = 332,000) prospective cohort study of cervical cytology and HPV DNA cotesting in U.S. women aged 30 years and older found that a negative Pap smear was associated with a low risk of developing CIN 3 or cancer (CIN 3+) for up to 5 years after the test (cumulative incidence of CIN 3+ at 3 and 5 years was 0.17% and 0.36%, respectively)
  4. d that a pap 3 months after a leep is on the 'soon' side, and sometimes can still be abnormal from inflammation. i would encourage you to get hpv tests along with your paps to be certain that all is healthy. continued good health wishes to you
  5. In addition to LSIL, some pap smears may show HSIL (high-grade squamous intraepithelial lesions). These lesions are typically taken much more seriously than LSIL, and a coloposcopy is normally performed as soon as an HSIL is discovered. HSIL are considered precancerous cells, and a person with these lesions may possibly be in the beginning.
  6. A pap smear is a screening test for cervical cancer and pre-cancer. The pap test is usually done in conjunction with an HPV test. There are many causes of abnormal pap smears, and most can be managed in the office. Once your test comes back abnormal, your provider reviews the test results and decides on a plan of action

(B) Four categories of liquid-based cervical cytology: NILM, ASC-US, LSIL, and HSIL with cytomorphologic features of disease progression, i.e., increased nuclear enlargement, nuclear membrane irregularity, nuclear/cytoplasmic ratio, and chromatin coarseness (ThinPrep Pap smear, 50x magnification). Bottom, binarized classification of 4. HSIL stands for high grade squamous intraepithelial lesion. This is one step before cervical cancer and if that's what the pap said, you need a colposcopy and cervical biopsy. CT usually means chlamydia was negative. rfx HPV means reflex HPV in the event that the pap is ASCUS. HPV is positive for most HSIL Promoting Health of Women and Future Babies. You May be Able to Make a Difference if You Have Abnormal Pap Smear Results. If you were diagnosed with high-grade squamous intraepithelial lesion (HSIL) or cannot rule out HSIL, you may be eligible to enroll in a clinical trial being conducted at UAMS for treating HSIL using an HPV therapeutic vaccin

What an LSIL Pap Smear Result Means - Verywell Healt

Aside from CIN 3, here are some terms you may find on your Pap smear or biopsy report: Squamous intraepithelial lesion (SIL). Squamous is a type of cell in the tissue covering the cervix pathological HSIL. Please note that cytological LSIL is not equivalent to histopathological CIN1 and cytological HSIL is not equivalent to histopathological CIN2,3. The current guidelines expand clinical indications for HPV testing based on studies using FDA-approved, validated HPV assays. Management decisions based on results using HPV test Cytology (Anal Pap) Negative or normal-When the pathologist examined the cells from the Pap smear under a microscope, s/he found no abnormal cells or signs of HPV-related changesAnal cytology is a fairly good indicator of who should be examined and who might have HSIL, but it is not the best way to determine the severity of SIL nor is it the best way to diagnose invasive anal cancer Most women don't think about their cervix until they have to get a Pap smear. As if the pelvic exam wasn't stressful enough, getting the news that you had abnormal Pap or positive HPV results, especially when accompanied by words like cervical dysplasia, biopsy, or pre-cancerous, can spin you out with worry. I get it. We're not given much intel on what all those test. These cases are detectable only with tests for HPV DNA such as Southern blot or PCR and not by Pap smear. The risk of progression to HSIL or cancer is 0.08% per year, or a 3.7% lifetime risk

Abnormal Pap Smear and Diagnosis of High-Grade Vaginal

  1. A Pap test, also called a Pap smear, is often part of a pelvic exam. The word Pap is short for Papanicolaou, which is the last name of the doctor who studied changes in cervical cells. A Pap test is usually done at age 21 unless you have special risks such as immune problems or HIV
  2. A Pap test is a procedure that screens women for signs of cervical cancer. An abnormal Pap smear doesn't always mean cervical cancer, though. In fact, most women who get abnormal Pap smear results don't have cancer of the cervix. Other causes of an abnormal Pap smear include infection, inflammation, and HPV
  3. A Pap smear is a screening mechanism only, not a diagnostic test. An abnormal or positive Pap smear does not mean that you have cervical cancer. It simply indicates that unusual cells have been detected on the cervix and that additional diagnostic testing may be required. These unusual cells can include any of the following

The PAP-TEST (PAP smear, Papanicolaou test) is a screening test used in gynecology. Main purpose of the test is to detect pre-cancerous lesions called squamous intraepithelial lesion (SIL), which are often caused by sexually transmitted human papillomaviruses. The test may also detect infections and abnormalities in the endocervix and endometrium The Pap test has now become part of routine physical examination for individuals with female reproductive parts to detect and monitor the presence of precancerous or cancerous cells on the cervix that may progress into cervical cancer. The test results from a Pap smear can go one of three ways: NORMAL, UNCLEAR, ABNORMAL Pap smear revealed that 78% had an inflammatory smear and 18% had a positive Pap smear. The result of Pap smear was considered positive if it revealed LSIL, HSIL, carcinoma in situ or invasive cancer

Abnormal Pap Smear: What an LSIL Result Might Mean for You

The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), cervical smear (BE), cervical screening (BE), or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or colon (in both men and women). Abnormal findings are often followed up by more sensitive diagnostic. HSIL - high-grade dyskaryosis. (a) Separated cells in a conventional smear showing a streak of separated cells showing the typical features of high-grade dyskaryosis: irregularly dispersed chromatin and nuclear outlines, immature cytoplasm; NC ratio variable but well over 50% in most of the cells. In this case there is hyperchromasia and the. HSIL - High-grade squamous intraepithelial lesions This result is also called moderate or severe dysplasia. It indicates that HPV is present and is causing more serious changes. These could turn into cancer if left untreated. A Pap smear is a medical exam used to determine if a woman has cervical cancer. It's performed b The ThinPrep ® Pap test is the only Pap test with FDA-approved labeling citing multiple peer-reviewed publications supporting increased glandular disease detection compared to the conventional pap. 9,10,11,12,13,14. Sensitivity for cervical adenocarcinoma8 My daughter recently had the Leep procedure done because her pap smear was HSIL. She was diagnosed between Cin 2 and Cin 3 based on the biopsy and the LEEP. The doctor said she is healing fine, the EC read mor

Abnormal Cervical Cancer Screening Test Results ACO

  1. Distinguish HSIL from mimickers (e.g. atrophy, immature metaplasia) Distinguish morphologically equivocal LSIL / CIN I versus CIN II Professional disagreement on diagnosis when HSIL is in consideration Biopsies showing ≤ LSIL in patients at high risk for missed HSIL based on prior Pap / HPV testing result
  2. A Pap smear (Pap test) is primarily a screening test for cervical cancer. It is used to detect abnormal or potentially abnormal cells from the vagina and the cervix, the narrow bottom portion of a woman's uterus. Various bacterial, fungal, and viral infections of the uterus may also be detected using this test
  3. Doctors and pathologists use a well-established system to assign a grade to the precancerous changes that can be seen on a Pap smear. The grade depends on just how abnormal the cervix cells look.
  4. Cervix - HSIL / CIN III / severe dysplasia. Usually single, small, round / oval cells with scant cytoplasm and increased N/C ratio (greater than 1/2
  5. A pap smear is a screening to test women for cervical cancer, according to the American College of Obstetricians and Gynecologists (ACOG). It can detect abnormal cervical cells to help find early cervical cancers. These routine screenings have greatly reduced the number of new cervical cancers diagnosed and deaths from the disease each year
  6. 0.5% Pap Smear results are HSIL (High Grade Squamous Intraepithelial Lesions) and less than 0.5% indicate Cancer. 0.2 - 0.8 % are AGC-NOS (Atypical Glandular Cells - Not Otherwise Specified.) With liquid-based preparations (LBPs), which are today common in developed countries, 2.9% are LSIL but the median incidence of HSIL continue to be 0.5%

Cervical dysplasia: Is it cancer? - Mayo Clini

  1. SIL can be low-grade (LSIL) or high-grade (HSIL). LSIL is very common, almost always indicates an HPV infection and usually goes away on its own without treatment (but may also indicate mild pre-cancerous changes) HSIL indicates more serious changes. Carcinoma in situ (CIS) is a severe form of HSIL and most likely to progress to cancer
  2. Number: 0443 (Replaces CPB 359) Policy. Consistent with guidelines from the U.S. Preventive Services Task Force (USPSTF) and the American College of Obstetricians and Gynecologists (ACOG), Aetna considers annual cervical cancer screening with conventional or liquid-based Papanicolaou (Pap) smears a medically necessary preventive service for nonhysterectomized women age 21 years and older
  3. In summary, 71 of 107 patients (66.4%) with a Pap smear interpretation of glandular cell abnormality had a follow-up sample, and 24 (33.8%) of these had a carci-noma (adenocarcinoma, carcinoma in situ, or SCC) or HSIL diagnosis. The Pap smears of 13 of these 24 (54.2%) were flagged as R on RPS. Finally and mos
  4. g (ah, finally some better news!)
  5. (ASCUS or LSIL), give periodic Pap tests until the abnormality resolves, or a colposcopy referral for persistent lesions. Women with glandular abnormalities (AGUS) usually are referred for colposcopy. Women with HSIL usually are referred for colposcopy. Women with HSIL should be treated to remove or destroy the abnormal cells
  6. ed significance (ASCUS) in 0.3%, squamous intraepithelial lesion (SIL) in 3.4% which includes low grade squamous intraepithelial lesion (LSIL) (2.7%) and high grade squamous intraepithelial lesion (HSIL) 0.7%. Invasive carcinoma was seen in 1.3% cases
  7. the woman is under 25, she should have a repeat Pap test in a year. women with LSIL should have colposcopy. For HSIL, either colposcopy or a loop electrosurgical procedure is recommended for women 25 and older. For women under 25, colposcopy is recommended. 3. Atypical glandular cells and adenocarcinoma in situ (on a Pap test

HSIL Pap smear, colposcopy biopsy result show inflamation

Only 15% of LSIL progress to HSIL Following a diagnosis of LSIL on Pap smear, colposcopic exam is performed with biopsy of any lesion to confirm the diagnosis If confirmatory biopsy, follow-up with Pap smears every 4-6 months If discordant biopsy, additional sampling may be necessar With regards to Pap smear results which indicated premalignant diagnoses, HSIL had the shortest wait time to colposcopy service, with a median of 67 days, followed by ASC-H at 80 days, while AGC had the longest time to evaluation of a median of 108 days. Final pathologic diagnosis by Pap smear diagnosis and time to diagnosi Certain changes seen on a pap test are suggestive of an HPV infection (see back). An HPV test can be performed using the same cells from a pap test. HPV testing is currently only recommended for certain borderline pap results (ASC-US in women 25 and older) or for women 30 and older as part of co-testing (pap plus HPV testing) what to do if i had a abnormal pap smear in 2001 and now have hgsil cin 2? Dr. Carrie Champine answered. 18 years experience Obstetrics and Gynecology. Followup with dr!: If your pap showed HGSIL, you need to have a colposcopy done. If you already did and the biopsy shows CIN 2, you will likely need a procedure to remo.

Atypical squamous cells cannot exclude HSIL (ASC-HThis Is What An Abnormal Pap Smear Means—And What ComesWhat an Abnormal Pap Smear Really Means—and What ComesLearnOncologyPap smear abnormal cells | General center | SteadyHealthPap smear - wikidoc

c One of 2 subjects was lost to follow-up after 2 HSIL Pap smears, that is, had repeated high-grade cytology only. The other was confirmed to be CIN 2/CIN 3/CIS. The other was confirmed to be CIN. Follow-up of the three carcinoma smears revealed three ICR (one followed by HSIL in a repeat Pap smear before ICR). The sensitivity for the detection of ICR by carcinoma smears was 50%, with a specificity and positive predictive value (PPV) of 100%. Conclusion: Few (∼3%) of the routine follow-up Pap smears after CC patients receiving curative. Follow-up of abnormal gynecologic cytology: a College of American Pathologists Q-probes study of 16132 cases from 306 laboratories. Arch Pathol Lab Med 2000 ;124:665-71. Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance Pap smear 1. DR.GEORGE PAPANICOLAOU 2. The first workshop was held in 1988, to reduce widespread confusion among laboratories and clinicians created by the use of multiple classification systems and inconsistently defined numerical grading conventions.Earlier versions of bethesda include 3 categories of adequacy: Satisfactory Unsatisfactory Borderline.The 2001 bethesda system eliminates the.